| Registro completo |
| Provedor de dados: |
J. Venom. Anim. Toxins
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| País: |
Brazil
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| Título: |
Scorpion (Buthus tamulus) venom toxicity on cardiopulmonary reflexes involves kinins via 5-HT3 receptor subtypes
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| Autores: |
BAGCHI,S.
DESHPANDE,S. B.
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| Data: |
2001-01-01
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| Ano: |
2001
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| Palavras-chave: |
Bezold-Jarisch reflex
Aprotinin
Bradykinin
Indian red scorpion
Ondansetron
Buthus tamulus
Kinins
5-HT3 receptors
Cardiopulmonary reflexes
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| Resumo: |
The mechanisms underlying the action of Indian red scorpion Buthus tamulus (BT) venom-induced augmentation of cardiopulmonary reflexes elicited by intravenous injection of 5-HT were examined in urethane anaesthetized rats. The 5-HT produced a concentration-dependent increase in time-response area of bradycardiac response, with the responses at submaximal concentrations shifted to the left after exposure to BT venom (20 µg/kg, IV). Aprotinin (6000 kallikrein inactivating unit, IV) as such had no effect on 5-HT reflex responses (bradycardia, hypotension, and apnea), but blocked the venom-induced reflex augmentation. While ondansetron (10 µg/kg, IV) completely blocked the 5-HT reflex responses, these reappeared partially after venom exposure (20 µg/kg). Exposure to bradykinin (50 µg/kg, IV) for 30 min also augmented the 5-HT-induced reflex responses similar to venom. The bradykinin-induced augmentation was also blocked by ondansetron. Results indicate that the venom-induced augmentation of cardiopulmonary reflexes is mediated through kinins sensitizing 5-HT3 receptor subtypes.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000100003
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| Editor: |
Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
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| Relação: |
10.1590/S0104-79302001000100003
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| Formato: |
text/html
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| Fonte: |
Journal of Venomous Animals and Toxins v.7 n.1 2001
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| Direitos: |
info:eu-repo/semantics/openAccess
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